To analyze efficiency and reliability of 4 modern neonatal ventilators under difficult test conditions. The ventilators tested were: Babylog 8000, BP 2001 (Bear Medical Systems), Sechrist IV 100 B (Sechrist Industries), Infant Star (Infrasonics INC). Gas flow generation was tested by comparison of preset flow values with no resistance in the circuit to flow values obtained during interposition of a resistance in the inspiratory circuit. A decrease in gas flow was observed when interposition of a resistance in the inspiratory circuit increased peak inspiratory pressure to 60 cmH2O (gas flow decreased by 8% to 24% depending on the ventilator tested). The pressure limiting valve and the positive end-expiratory pressure valve were also evaluated in order to test their behaviour under different flow conditions. Flow-dependence of the pressure was noted for all ventilators except Babylog 8000. Assessment of the reliability of pressure monitoring revealed either 'under' or 'over' estimation of peak inspiratory pressure and positive end-expiratory pressure depending on the ventilator tested. For the best clinical use of mechanical ventilators, neonatologists should be aware of these limitations. Therefore a regular assessment of ventilator performance and monitoring reliability is recommended.  www.jiuxin-med.com